Druq design Essay Example | Topics and Well Written Essays - 500 words

Druq design - Essay Example Inside the cell, the HIV reverse transcriptase converts the viral RNA into DNA; this DNA is transported into the cell nucleus where it is inserted into the human genome by the HIV integrase enzyme. The HIV DNA may lie dormant, but is later expressed for the synthesis of new HIV proteins and enzymes. The HIV protease is active at this stage of the life cycle where its role is to cut long protein strands to form viral cores. The development of the pathogenic effects of HIV is characterized by the interaction between viral and host factors. A broad spectrum of antiviral strategies was developed for each step of the viral replication cycle. Every stage in the life cycle, and every gene product of HIV is a potential target. Host proteins that are recognized to have an essential role in the viral life cycle are also targets of HIV therapy (Nielsen, Pedersen, & Kjems, 2005). As of 2007, more than 20 anti-HIV drugs have been approved (De Clerq, 2007). The drugs block the enzyme activity of any of the enzyme that HIV needs to replicate inside host cells: reverse transcriptase, protease, fusion inhibitors, and lately integrase inhibitors. The norm is to utilize highly active antiretroviral therapy (HAART), which combines two or three drugs to overcome the development of drug resistant targets. Nevertheless, multi-drug resistant HIV continue to develop due to the high viral mutation rates. Integrase is the chosen target for the drug to be designed for HIV treatment; it facilitates the insertion of the double-stranded DNA copy of the HIV RNA genome into the host genome, an absolute requirement for viral replication (LaFemina, et al., 1992). Integration of the HIV DNA requires 3 processing of the final two bases of the viral DNA long terminal repeat (LTR), and DNA strand transfer activity. HIV integrase was found to be composed of several multimers with functional domains sufficient for 3 processing and

Migrant labors workers abuse Essay Example | Topics and Well Written Essays - 1000 words

Migrant labors workers abuse - Essay Example The most astonishing part is that these workers usually belong to poor countries of the world. They migrate in order to identify better working opportunities. But usually what the find is extreme hard work without full compensation of their struggles. This subsequently raises a question that why migrant labor workers rights are abused? Here, it will be argued that the primary reason for such massive mistreatment is the workers association with poor and under developed countries. The UAE’s construction boom which was started in early 2000 was a huge source of recruitment for labor workers from all over the world and specifically from poor countries. It was reported that more than 500,000 labor workers employed by different construction companies were migrants from countries such as Pakistan, India and Bangladesh. Moreover, the country’s 95% workforce constituted of these migrant workers. It is a harsh reality that the huge towers of UAE are actually built while sacrificing the rights of thousands of poor people (UAE: Workers Abused in Construction Boom, 2006). One of the major construction projects undergoing in UAE is Saadiyat Island. This project is owned by UAE’s Tourists Development and Investment Company (TDIC). International news agencies have observed that the company is not abiding by its own employment rules and regulations. Hence majority of its workers are actually living and working in extreme conditions. On the other hand if they try to take action then company expels them out. The situation is even worse at the building site of New York University’s campus in UAE (Batty, 2013). It has been identified that the construction companies are actually confiscating the migrant workers passports while reducing their chances to move out of UAE. Moreover, TDIC pledged to provide accommodation to its workers in Saadiyat’s village but the labor workers are living in inferior conditions in